1. NAD+ (Nicotinamide Adenine Dinucleotide) Testing

  • What is NAD+? NAD+ is a coenzyme found in every cell in the body, crucial for energy production, DNA repair, and maintaining healthy metabolism. It declines with age, which is thought to contribute to aging processes and a decline in cellular function.
  • How is NAD+ related to aging? NAD+ supports the activity of sirtuins, proteins involved in longevity, and helps repair DNA. Reduced levels of NAD+ are associated with cellular aging, decreased energy, and cognitive decline.
  • Testing Method: Blood tests can measure NAD+ levels to assess cellular energy metabolism and aging markers. The test results help in crafting personalised anti-aging treatments.
  • Sample Requirement: Typically, a blood sample is required.
  • Turnaround Time (TAT): Results are usually available within a week, depending on the lab.
  • Use in Therapy: Based on NAD+ levels, treatments often include NAD+ supplements or NAD+-boosting peptides like MOTS-c to restore cellular energy and slow down aging.

2. SASP (Senescence-Associated Secretory Phenotype) Testing

  • What is SASP? SASP refers to the inflammatory factors released by senescent cells (cells that have stopped dividing but remain in the body). These cells contribute to aging and chronic diseases by promoting inflammation.
  • How does SASP impact health? SASP-related inflammation is linked to age-related diseases like cardiovascular disease, diabetes, and neurodegenerative disorders. Reducing SASP activity is a key target for anti-aging interventions.
  • Testing Method: SASP testing involves measuring pro-inflammatory cytokines, chemokines, and growth factors in blood or tissue samples. These markers indicate the presence and activity of senescent cells.
  • Sample Requirement: Blood or tissue biopsy may be required, depending on the specific SASP markers being measured.
  • Turnaround Time (TAT): Testing results typically take 1-2 weeks.
  • Use in Therapy: SASP inhibition therapies, like senolytic drugs or certain peptides (such as FOXO4), target the reduction of senescent cells and their inflammatory output, potentially reversing some aspects of aging.

3. Telomere Testing

  • What are Telomeres? Telomeres are protective caps at the ends of chromosomes that shorten as cells divide. Short telomeres are associated with cellular aging, reduced regenerative capacity, and increased risk of age-related diseases.
  • How does telomere length affect health? Short telomeres are a marker of biological aging. Telomere testing is used to estimate an individual’s biological age compared to their chronological age.
  • Testing Method: Telomere length is measured through blood tests, using techniques such as quantitative PCR (qPCR) to determine the average length of telomeres in white blood cells.
  • Sample Requirement: Blood sample is commonly required.
  • Turnaround Time (TAT): Results can take 1-2 weeks.
  • Use in Therapy: Based on telomere length results, treatments like telomerase-activating peptides (such as Epithalon) can be used to potentially lengthen telomeres and slow down cellular aging​​​.