The article “The Effectiveness and Safety of Mesenchymal Stem Cells in the Treatment of Osteoarthritis: A Systematic Review and Meta-analysis of 28 Randomized Controlled Trials” evaluates MSC therapy for osteoarthritis. The study included 1494 participants and found that MSCs significantly reduced pain, stiffness, and physical dysfunction, with effects lasting at least 12 months. MSC therapy showed no significant difference in adverse events compared to control groups. However, the generalizability of the results is limited by the low quality of evidence.