The article “Role of Human Mesenchymal Stem Cells in Regenerative Therapy” reviews the applications of mesenchymal stem cells (MSCs) in regenerative medicine. MSCs are multipotent cells capable of differentiating into various cell types and secreting immunomodulatory molecules, creating a regenerative environment. The review covers quality control parameters, mechanisms of action like trans-differentiation and mitochondrial transfer, and discusses MSCs’ roles in tissue regeneration and engineering, including applications in bioprinting and organoid technology.