The article “Mesenchymal Stem Cell Transplantation for the Treatment of Age-Related Musculoskeletal Frailty” reviews the potential of MSCs in treating conditions like osteoporosis and sarcopenia, which are increasingly prevalent due to aging populations. MSC transplantation is highlighted as a promising regenerative therapy to counteract bone and muscle deterioration. The review summarizes current understanding, therapeutic mechanisms, and the need for further research to develop effective treatments.