The article “Mesenchymal stem-cell therapy for perianal fistulas in Crohn’s disease: a systematic review and meta-analysis” evaluates the efficacy and safety of MSC therapy for treating perianal fistulas in Crohn’s disease. It includes 13 trials showing that MSC therapy significantly improves fistula healing rates compared to controls, with 63% of patients achieving clinical healing. Autologous MSCs were more effective than allogeneic MSCs, and no significant increase in adverse events was reported.