The article “Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics” discusses MSC therapy for aging frailty, a syndrome marked by physiological decline. MSCs’ regenerative and anti-inflammatory properties show promise in ameliorating frailty symptoms, improving organ function, and overall health. The review covers MSCs’ mechanisms and their therapeutic potential, emphasizing the need for further large-scale studies to confirm efficacy and safety.